Marmoset PFC Connectome

Exploring Connectional Architecture of the Prefrontal Cortex (PFC)


Prefrontal cortex (PFC) plays a central role in orchestrating various cognitive functions and evolved greatly in primate lineage. The understanding of its connectional architecture in a primate model is, therefore, critical in extrapolating the animal data to humans. Here we report a brain-wide, connectomics mapping of the marmoset PFC projections using serial two-photon tomography imaging.


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Brain/MINDS Marmoset Connectivity Atlas

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Watakabe., A, Skibbe, H., Nakae, K., Abe, H., Ichinohe, N., Wang, J., Takaji, M., Mizukami, H., Woodward, A., Gong, R., Hata, J., Okano, H., Ishii, S. & Yamamori., T. Connectional architecture of the prefrontal cortex in the marmoset brain. bioRxiv 2021.12.26.474213; doi: https://doi.org/10.1101/2021.12.26.474213

H. Skibbe, M.F. Rachmadi, K. Nakae, C. E. Gutierrez, J. Hata, H. Tsukada, C. Poon, K. Doya, P. Majka, M. G. P. Rosa, H. Okano, T. Yamamori, S. Ishii, M. Reisert, A. Watakabe. The Brain/MINDS Marmoset Connectivity Atlas: Exploring bidirectional tracing and tractography in the same stereotaxic space. bioRxiv 2022; doi: https://doi.org/10.1101/2022.06.06.494999

Contributors and Acknowledgements :

Laboratory for Molecular Analysis of Higher Brain Function : Experiments.

Brain Image Analysis Unit : Image processing.

Connectome Analysis Unit : Viewer development, atlasing, hosting.

As part of Brain/MINDS project, this work was supported by Japan Agency for Medical Research and Development (AMED).

Contact: tracerdata@ml.riken.jp

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