Marmoset PFC Connectome

Exploring Connectional Architecture of the Prefrontal Cortex (PFC)

Prefrontal cortex (PFC) plays a central role in orchestrating various cognitive functions and evolved greatly in primate lineage. The understanding of its connectional architecture in a primate model is, therefore, critical in extrapolating the animal data to humans. Here we report a brain-wide, connectomics mapping of the marmoset PFC projections using serial two-photon tomography imaging.

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Related publications :

Watakabe., A, Skibbe, H., Nakae, K., Abe, H., Ichinohe, N., Wang, J., Takaji, M., Mizukami, H., Woodward, A., Gong, R., Hata, J., Okano, H., Ishii, S. & Yamamori., T. Connectional architecture of the prefrontal cortex in the marmoset brain. bioRxiv 2021.12.26.474213; doi:

H. Skibbe, M.F. Rachmadi, K. Nakae, C. E. Gutierrez, J. Hata, H. Tsukada, C. Poon, K. Doya, P. Majka, M. G. P. Rosa, H. Okano, T. Yamamori, S. Ishii, M. Reisert, A. Watakabe. The Brain/MINDS Marmoset Connectivity Atlas: Exploring bidirectional tracing and tractography in the same stereotaxic space. bioRxiv 2022; doi:

Contributors and Acknowledgements :

Laboratory for Molecular Analysis of Higher Brain Function : Experiments.

Brain Image Analysis Unit : Image processing.

Connectome Analysis Unit : Viewer development, atlasing, hosting.

As part of Brain/MINDS project, this work was supported by Japan Agency for Medical Research and Development (AMED).